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dc.rights.licenseCC BY-NC-ND. Users may download and share copies with attribution in accordance with a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 license. No commercial use or derivatives are permitted without the explicit approval of the author.
dc.contributorGilbert, Ryan
dc.contributorUllal, Chaitanya
dc.contributorOzisik, Rahmi
dc.contributor.advisorPalermo, Edmund
dc.contributor.authorHsu, Alexander
dc.date.accessioned2022-09-14T19:23:44Z
dc.date.available2022-09-14T19:23:44Z
dc.date.issued2021-08
dc.identifier.urihttps://hdl.handle.net/20.500.13015/6076
dc.descriptionAugust 2021
dc.descriptionSchool of Engineering
dc.description.abstractDue to the refractory nature of the central nervous system (CNS), injuries such as spinal cord injury (SCI) trigger a complex injury cascade. Currently, no effective therapeutics exist to reverse the outcomes of progressive secondary injuries caused by SCI. The debilitating, long-term effects of SCI have created the need for a controlled extended-release drug delivery platform. 17-Estradiol (E2) is known to have neuroprotective, neurotrophic, and immunosuppressive properties making it a promising therapeutic for CNS injuries. The central motivation of this work is to examine structure-property relationships in polymerized estrogen materials to create tunable material properties and release kinetics. The design, testing, and characterization of poly(pro-E2) biomaterial scaffolds is reported and presents a promising drug delivery platform to target CNS injuries. The strategies employed in the synthesis of the library of poly(ester) and poly(carbonate) E2 prodrugs with varying chain modifiers presented is highly applicable to other polymer classes leaving limitless possibilities to tailor material properties and control drug release kinetics.
dc.languageENG
dc.language.isoen_US
dc.publisherRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofRensselaer Theses and Dissertations Online Collection
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectMaterials engineering
dc.titleStructure-property relationships in poly(pro-17-estradiol) materials and the effect on in vitro degradation kinetics
dc.typeElectronic thesis
dc.typeThesis
dc.date.updated2022-09-14T19:23:47Z
dc.rights.holderThis electronic version is a licensed copy owned by Rensselaer Polytechnic Institute (RPI), Troy, NY. Copyright of original work retained by author.
dc.description.degreeMS
dc.relation.departmentDept. of Materials Science and Engineering


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CC BY-NC-ND. Users may download and share copies with attribution in accordance with a Creative Commons
                            Attribution-Noncommercial-No Derivative Works 3.0 license. No commercial use or derivatives
                            are permitted without the explicit approval of the author.
Except where otherwise noted, this item's license is described as CC BY-NC-ND. Users may download and share copies with attribution in accordance with a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 license. No commercial use or derivatives are permitted without the explicit approval of the author.