Microanalysis of stomach cancer glycosaminoglycans

Authors
Weyers, Amanda
Yang, Bo
Park, Jong Hwan
Kim, Yong Seok
Kim, Sun Moon
Lee, Sang Eok
Zhang, Fuming
Lee, Kyung Bok
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Issue Date
2013-10-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
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Full Citation
Microanalysis of stomach cancer glycosaminoglycans, A. Weyers, B. Yang, J.-H. Park, Y.-S. Kim, S.-M. Kim, S.-E. Lee, F. Zhang, K. B. Lee, R. J. Linhardt, Glycoconjugate Journal, 30, 701–707, 2013.
Abstract
Glycosaminoglycans (GAGS) are anionic, linear, polysaccharides involved in cell signaling. The GAG content, composition and structure of human tissue have been suggested to play a role in cancer and might provide useful diagnostic or prognostic markers. The current study examines 17 stomach tissue biopsy samples taken from normal individuals and from patients with gastric cancers. An ultrasensitive liquid chromatography (LC) - mass spectrometry assay was applied to individual biopsy samples as small 250 μg providing GAG content and disaccharide composition. The results of these analyses show a significant increase in non-sulfated chondroitin/dermatan sulfate concentration in all cancer samples when compared to normal tissues. In addition in advanced gastric cancer, a significant decrease is observed in hyaluronan.
Description
Glycoconjugate Journal, 30, 701–707
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Springer
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Glycoconjugate Journal
https://harc.rpi.edu/
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A full text version is available in DSpace@RPI