Microanalysis of stomach cancer glycosaminoglycans
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Authors
Weyers, Amanda
Yang, Bo
Park, Jong Hwan
Kim, Yong Seok
Kim, Sun Moon
Lee, Sang Eok
Zhang, Fuming
Lee, Kyung Bok
Linhardt, Robert J.
Issue Date
2013-10-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Glycosaminoglycans (GAGS) are anionic, linear, polysaccharides involved in cell signaling. The GAG content, composition and structure of human tissue have been suggested to play a role in cancer and might provide useful diagnostic or prognostic markers. The current study examines 17 stomach tissue biopsy samples taken from normal individuals and from patients with gastric cancers. An ultrasensitive liquid chromatography (LC) - mass spectrometry assay was applied to individual biopsy samples as small 250 μg providing GAG content and disaccharide composition. The results of these analyses show a significant increase in non-sulfated chondroitin/dermatan sulfate concentration in all cancer samples when compared to normal tissues. In addition in advanced gastric cancer, a significant decrease is observed in hyaluronan.
Description
Glycoconjugate Journal, 30, 701–707
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Microanalysis of stomach cancer glycosaminoglycans, A. Weyers, B. Yang, J.-H. Park, Y.-S. Kim, S.-M. Kim, S.-E. Lee, F. Zhang, K. B. Lee, R. J. Linhardt, Glycoconjugate Journal, 30, 701–707, 2013.
Publisher
Springer
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
15734986
2820080
2820080