Recent Progress of Marine Polypeptides as Anticancer Agents
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Authors
Zheng, Lanhong
Xu, Yixin
Lin, Xiukun
Yuan, Zhixin
Liu, Minghua
Cao, Shousong
Zhang, Fuming
Linhardt, Robert J.
Issue Date
2018-01-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Background: Marine environment constitutes an almost infinite resource for novel anticancer drug discovery. The biodiversity of marine organisms provides a rich source for the discovery and development of novel anticancer peptides in the treatment of human cancer. Marine peptides represent a new opportunity to obtain lead compounds in biomedical field, particularly for cancer therapy. Objective: Providing an insight of the recent progress of patented marine peptides and presenting information about the structures and mechanistic mode of anticancer activities of these marine peptides. Methods: We reviewed recent progress on the patented anticancer peptides from marine organisms according to their targets on different signal pathways. This work focuses on relevant recent patents (2010-2018) that entail the anticancer activity with associated mechanism and related molecular diversity of marine peptides. The related cellular signaling pathways for novel peptides that induce apoptosis and affect tubulin-microtubule equilibrium, angiogenesis and kinase activity that are related to the anticancer and related pharmacological properties are also discussed. Results: The recent patents (2010-2018) of marine peptides with anticancer activity were reviewed, and the anticancer activity of marine peptides with associated mechanism and related molecular diversity of marine peptides were also discussed. Conclusion: Marine peptides possess chemical diversity and display potent anticancer activity via targeting different signal pathways. Some of the marine peptides are promising to be developed as novel anticancer agents.
Description
Recent Patents on Anticancer Drug Discovery, 13
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Recent Progress of Marine Polypeptides as Anticancer Agents, L. Zheng, X. Lin, Z. Yuan, M. Liu, S. Cao, F. Zhang, R.J. Linhardt, Recent Patents on Anticancer Drug Discovery, 13, 2018.
Publisher
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
22123970
15748928
15748928