Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides

Authors
Xu, Han
Shen, Baoxing
Qiao, Meng
Linhardt, Robert J.
Zhang, Xing
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2021-04-15
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides, H. Xu, B. Shen, M. Qiao, R. J. Linhardt, X. Zhang, Carbohydrate Polymers, 258, 117672, 2021.
Abstract
Glycans and glycoconjugates in nature include macromolecules with important biological activities and widely distributed in all living organisms. These oligosaccharides and polysaccharides play important roles in a variety of normal physiological and pathological processes, such as cell metastasis, signal transduction, intercellular adhesion, inflammation, and immune response. However, the heterogeneity of naturally occurring glycans and glycoconjugates complicates detailed structure-activity relationship studies resulting in an incomplete understanding of their mechanisms of action and hindering further applications. Therefore, the synthesis of homogeneous, or nearly homogeneous, structurally defined glycans is of great significance for the development of carbohydrate-based drugs. One-pot synthesis represents the fastest strategy to assemble oligosaccharides and polysaccharides, although unfortunately, typically relies on random assembly. In this review, we examine the progress that has been made in the controlled one-pot synthesis of homogeneous or nearly homogeneous oligosaccharides and polysaccharides providing a broad spectrum of options to access size-controlled glycan products.
Description
Carbohydrate Polymers, 258, 117672
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Carbohydrate Polymers
https://harc.rpi.edu/
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