Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides

No Thumbnail Available
Authors
Xu, Han
Shen, Baoxing
Qiao, Meng
Linhardt, Robert J.
Zhang, Xing
Issue Date
2021-04-15
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract
Glycans and glycoconjugates in nature include macromolecules with important biological activities and widely distributed in all living organisms. These oligosaccharides and polysaccharides play important roles in a variety of normal physiological and pathological processes, such as cell metastasis, signal transduction, intercellular adhesion, inflammation, and immune response. However, the heterogeneity of naturally occurring glycans and glycoconjugates complicates detailed structure-activity relationship studies resulting in an incomplete understanding of their mechanisms of action and hindering further applications. Therefore, the synthesis of homogeneous, or nearly homogeneous, structurally defined glycans is of great significance for the development of carbohydrate-based drugs. One-pot synthesis represents the fastest strategy to assemble oligosaccharides and polysaccharides, although unfortunately, typically relies on random assembly. In this review, we examine the progress that has been made in the controlled one-pot synthesis of homogeneous or nearly homogeneous oligosaccharides and polysaccharides providing a broad spectrum of options to access size-controlled glycan products.
Description
Carbohydrate Polymers, 258, 117672
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides, H. Xu, B. Shen, M. Qiao, R. J. Linhardt, X. Zhang, Carbohydrate Polymers, 258, 117672, 2021.
Publisher
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
1448617
EISSN