Surface modification of a polyethylene film for anticoagulant and anti-microbial catheter
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Authors
Zheng, Y.
Miao, J.
Zhang, F.
Cai, C.
Koh, A.
Simmons, T.J.
Mousa, S.A.
Linhardt, Robert J.
Issue Date
2016
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
A functional anticoagulant and anti-bacterial coating for polyethylene (PE) films is described. The stepwise preparation of this nanocomposite surface coating involves O2 plasma etching of PE film, carbodiimide coupling of cysteamine to the etched PE film, binding of Ag to sulfhydryl groups of cysteamine, and assembly of heparin capped AgNPs on the PE film. The nanocomposite film and its components were characterized by 1H-nuclear magnetic resonance spectroscopy, attenuated total reflectance-Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and field emission-scanning electron microscopy. The resulting PE films demonstrate anticoagulant activity using a hemoglobin whole blood clotting assay, and anti-bacterial activity against Bacillus cereus 3551 (Gram-positive) and Escherichia coli BL21 (Gram-negative) bacteria. The hydrophilicity of the heparin coated PE was determined by contact angle measurements; and the stability of the nanocomposite film, with respect to Ag leaching, was assessed by atomic absorption spectroscopy.
Description
Reactive & Functional Polymers,100, 142–150
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Surface modification of a polyethylene film for anticoagulant and anti-microbial catheter, Y. Zheng, J. Miao, F. Zhang, C. Cai, A. Koh, T. J. Simmons, S. A. Mousa, R. J. Linhardt, Reactive & Functional Polymers,100, 142–150, 2016.
Publisher
Elsevier