Peptide interactions with crystalline and nanoparticle materials
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Authors
Springli, Carl
Issue Date
2015-05
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Chemical engineering
Alternative Title
Abstract
Peptides are a class of molecules which offer a high degree of functional flexibility and simplicity which can be leveraged to develop molecules with high affinity and specificity toward a target. In this work, peptides are investigated for their efficacy in binding to crystalline and nanoparticle inorganic materials. In particular, peptides were screened for the growth inhibition of calcium oxalate monohydrate crystals and the ability to longitudinally link gold nanorods. A robust assay was developed for the high throughput screening of peptides, utilizing Fmoc peptide synthesis, automated image collection, and a machine learning algorithm to analyze images. This assay was used to evaluate the effects of peptide growth modifiers derived from osteocalcin in comparison to calcium oxalate crystal growth without modifiers and also with a known modifier.
Description
May 2015
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY