Synthesis and Evaluation of Anticancer Vaccine Candidate, C-Glycoside Analogs of sTn and PSA

Authors
Weïwer, M.
Huang, F.
Chen, C.C.
Yuan, X.
Tokuzaki, K.
Tomiyama, H.
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2008-09-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Synthesis and Evaluation of Anticancer Vaccine Candidate, C-Glycoside Analogs of sTn and PSA, M. Weïwer, F. Huang, C.-C. Chen, X. Yuan, K. Tokuzaki, H. Tomiyama, R. J. Linhardt, Chemical Glycobiology II: Glycopharmaceuticals and Glycovaccines, X. Chen, R. L. Halcomb, p. G. Wang, Eds., ACS Press, Chap. 10, pp. 175-195, 2008.
Abstract
Neuraminic acids are biologically important and occupy the terminal position of the glycoconjugate glycans on the outside of cells. Sialyl-Tn (sTn) is found on tumor-associated glycoprotein antigens present on the surface of cancer cells, including those associated with carcinomas of the breast, prostate, pancreas, colon, ovary, lung, and stomach. The sTn antigen is well known as a prognostic indicator and has proven to be an effective target for cancer therapy. Conjugate vaccines of sTn-KLH show remarkable immunogenicity, resulting in the production of both IgM and IgG type antibodies. The sTn Cglycoside was designed and synthesized and its KLH-conjugate was evaluated for immunogenicity in mice. Neuraminic acid C-glycosides such as sTn and polysialic acid (PSA) might be useful in preparing immunogens for active immunization against neuraminic acid containing glycoconjugates in the design and preparation of anti-cancer vaccines.
Description
Chemical Glycobiology II: Glycopharmaceuticals and Glycovaccines, X. Chen, R. L. Halcomb, p. G. Wang, Eds., ACS Press, Chap. 10, pp. 175-195
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
ACS Symposium Series
https://harc.rpi.edu/
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https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/bk-2008-0990.ch010