Enzymatic Synthesis of Glycosaminoglycans: Improving on Nature
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Authors
Avci, Fikri Y.
DeAngelis, Paul L.
Liu, Jian
Linhardt, Robert J.
Issue Date
2007-01-01
Type
Book chapter
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
The chemoenzymatic synthesis of glycosaminoglycan (GAG) analogs is described. This chapter is divided into three main sections, each describing the use of one enzyme family in GAG synthesis. First, the polysaccharide lyase enzymes are described. These enzymes play crucial role in obtaining GAG oligosaccharides. Second, GAG synthases, bacterial enzymes that transfer UDP-monosaccharides to acceptor oligosaccharide are described, to obtain homogenous oligosaccahrides and polysaccharides. Finally, GAG sulfotransferases, that play a major role in the biosynthesis, are described for the introduction of sulfo groups to the appropriate positions on the polysaccharide backbone.
Description
in Frontiers in Carbohydrate Chemistry, ACS Symposium Series 960, A. Demchenko, Ed., Chapter 15, pp 253-284, Oxford University Press, London
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Enzymatic Synthesis of Glycosaminoglycans: Improving on Nature, F.Y. Avci, P.L. DeAngelis, J. Liu, R.J. Linhardt, in Frontiers in Carbohydrate Chemistry, ACS Symposium Series 960, A. Demchenko, Ed., Chapter 15, pp 253-284, 2007, Oxford University Press, London.
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PubMed ID
DOI
ISSN
976156