Heparin Oligosaccharides as Potential Therapeutic Agents in Senile Dementia
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Authors
Ma, Qing
Cornelli, Umberto
Hanin, Israel
Jeske, Walter P.
Linhardt, Robert J.
Walenga, Jeanine M.
Fareed, Jawed
Lee, John M.
Issue Date
2007-05-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Heparin is a glycosaminoglycan mixture currently used in prophylaxis and treatment of thrombosis. Heparin possesses non-anticoagulant properties, including modulation of various proteases, interactions with fibroblast growth factors, and anti-inflammatory actions. Senile dementia of Alzheimer’s type is accompanied by inflammatory responses contributing to irreversible changes in neuronal viability and brain function. Vascular factors are also involved in the pathogenesis of senile dementia. Inflammation, endogenous proteoglycans, and assembly of senile plagues and neurofibrillary tangles contribute directly and indirectly to further neuronal damage. Neuron salvage can be achieved by anti-inflammation and the competitive inhibition of proteoglycans accumulation. The complexity of the pathology of senile dementia provides numerous potential targets for therapeutic interventions designed to modulate inflammation and proteoglycan assembly. Heparin and related oligosaccharides are known to exhibit anti-inflammatory effects as well as inhibitory effects on proteoglycan assembly and may prove useful as neuroprotective agents.
Description
Current Pharmaceutical Design, 13, 1607-1616
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Heparin Oligosaccharides as Potential Therapeutic Agents in Senile Dementia, Q. Ma, U. Cornelli, I. Hanin, J. M. Lee, W. P. Jeske, R. J. Linhardt, J. M. Walenga, J. Fareed, Current Pharmaceutical Design, 13, 1607-1616, 2007.
Publisher
Bentham Science
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
13816128