Recent advances in sulfotransferase enzyme activity assays
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Authors
Paul, Priscilla
Suwan, Jiraporn
Liu, Jian
Dordick, Jonathan S.
Linhardt, Robert J.
Issue Date
2012-06-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Sulfotransferases are enzymes that catalyze the transfer of sulfo groups from a donor, for example 3′-phosphoadenosine 5′-phosphosulfate, to an acceptor, for example the amino or hydroxyl groups of a small molecule, xenobiotic, carbohydrate, or peptide. These enzymes are important targets in the design of novel therapeutics for treatment of a variety of diseases. This review examines assays used for this important class of enzyme, paying particular attention to sulfotransferases acting on carbohydrates and peptides and the major challenges associated with their analysis.
Description
Analytical and Bioanalytical Chemistry, 403, 1491–1500
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Recent advances in sulfotransferase enzyme activity assays, P. Paul, J. Liu, J. S. Dordick, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 403, 1491–1500, 2012.
Publisher
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
16182650
16182642
16182642