C-2 Epimerization of N-Acetylglucosamine in an Oligosaccharides Derived from Heparan Sulfate
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Authors
Toida, Toshihiko
Vlahov, Iontcho R.
Smith, April E.
Hileman, Ronald E.
Linhardt, Robert J.
Issue Date
1996-01-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
The isolation of a heparan sulfate derived tetrasaccharide containing N-acetylmannosamine is described. The N-acetylmannosamine residue at the reducing terminus of heparin lyase derived tetrasaccharide is formed by base catalyzed C-2 epimerization of N-acetylglucosamine. This C-2 epimerization takes place under very mild conditions suggesting that this residue may be formed in small amounts under physiologic conditions.
Description
Journal of Carbohydrate Chemistry, 15, 351-360
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
C-2 Epimerization of N-Acetylglucosamine in an Oligosaccharides Derived from Heparan Sulfate, T. E. Toida, I. R. Vlahov, A. E. Smith, R. E. Hileman, R.J. Linhardt, Journal of Carbohydrate Chemistry, 15, 351-360, 1996.
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PubMed ID
DOI
ISSN
7328303