Controlling the properties and degradation kinetics of polyprodrug films
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Authors
Falcone, Phillip
Issue Date
2020-05
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Materials engineering
Alternative Title
Abstract
The intent of this project is to characterize the properties and the kinetics of release of polyprodrugs made from estradiol and curcumin to develop biomaterials to be used with neuroprotective applications. For both carbonate linked and ester linked varieties of estradiol polyprodrugs of estradiol, the thermal and mechanical properties of hexyl based and oligo(ethylene glycol) (oEG) based polyprodrugs were characterized, as well as the kinetics of prodrug release. It was observed that the presence of oEG/hexyl groups had a more substantial effect on stiffness, hardness, and degradation rate than the type of linkage. It was also observed that for short timescale under human body mimetic conditions, the polyprodrugs of estradiol examined in this study all exhibited similar release kinetics. The chemistry of synthesizing curcumin-co-PEG polyprodrugs was explored, and the thermal and mechanical properties tested. A lack of control of molecular weight lead to lack of predictable property trends across the different curcumin containing polymers that were studied. This project is a continuation of the work on poly(pro-estradiol) materials by D'Amanto et al.
Description
May 2020
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY