Glycoconjugate synthesis using chemoselective ligation
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Authors
Cheng, Shuihong
Wantuch, Paeton L.
Kizer, Megan E.
Middleton, Dustin R.
Wang, Ruitong
Dibello, Mikaela
Li, Mingli
Wang, Xing
Li, Xuebing
Ramachandiran, Vasanthi
Issue Date
2019-01-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.
Description
Organic & Biomolecular Chemistry, 17, 2646-2650
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Glycoconjugate synthesis using chemoselective ligation, S. Cheng, P.L. Wantuch, M.E. Kizer, D.R. Middleton, R. Wang, M. DiBello, M. Li, X. Wang, X. Li, V. Ramachandiran, F.Y. Avci, F. Zhang, Xing Zhang, R.J. Linhardt, Organic & Biomolecular Chemistry, 17, 2646-2650, 2019.
Publisher
Royal Society of Chemistry
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
14770520