Solvation and interactions in aqueous, organic, and biomolecular systems at nanoscale interfaces
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Authors
Wu, Eugene
Issue Date
2015-08
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Chemical and biological engineering
Alternative Title
Abstract
As part of ongoing and future work, we present applications of the INDUS method to study the protein surface hydrophobicity of human gamma-D crystallin, a structural protein in the eye lens, and its P23T variant with a single point mutation from proline23 to threonine. The P23T variant has been implicated in self-aggregation leading to the formation of cataracts. Finally, we also present results on solvation of self-assembled monolayers of immobilized ionic head groups near hydrophobic head groups, which are of theoretical and practical/experimental interest.
Description
August 2015
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY