Synthesis, structural, and biological studies on a pseudodisaccharide containing a bicyclic, bridged carba-sugar

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Abstract

Two carba-sugar containing pseudodisaccharide diastereomers have been synthesized from a racemic bicyclooctene derivative. The determination of the absolute configurations was carried out by means of CD measurements, CD calculations and X-ray diffraction. The compounds showed moderate competitive inhibitory effects on chondroitin AC-I lyase.

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Tetrahedron: Asymmetry, 22, 1404-1410
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Synthesis, structural, and biological studies on a pseudodisaccharide containing a bicyclic, bridged carba-sugar, Z. Fejes, T. Kurtán, G. Raabe, J. Fleischhauer, L. Szilágyi, A. Bényei, Z. Gál, W. Zhao, R. J. Linhardt, M. Cygler, P. Herczegh, Tetrahedron: Asymmetry, 22, 1404-1410, 2011.

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1362511X
9574166

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