In Vivo Activity of Microbial Heparinase
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Authors
Langer, R.
Linhardt, Robert J.
Larsen, A.K.
Cooney, C.L.
Tapper, D.
Klein, M.
Issue Date
1982
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Heparin, prepared from mammalian intestinal mucosa, is the most widely used anticoagulant. It has been estimated, however, that the use of heparin leads to complications such as bleeding 8-33% of the time1. Of all prescription drugs, heparin is the drug responsible for the greatest number of deaths in otherwise healthy patients 2. For these reasons, it would be extremely useful to have a method to control blood heparin levels. We propose that this might be accomplished by using heparinase, an enzyme which specifically degrades the anticoagulant activity of heparin. In this report, we discuss the in vivo activity of both free and immobilized heparinase.
Description
Transactions of the American Society for Artificial Internal Organs, 28, 387-390
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
In Vivo Activity of Microbial Heparinase, R. Langer, R.J. Linhardt, A.K. Larsen, C.L. Cooney, D. Tapper, M. Klein, Transactions of the American Society for Artificial Internal Organs, 28, 387-390 (1982).