A study of shape-dependent partial volume correction in PET imaging using ellipsoidal phantoms fabricated via rapid prototyping

Authors
Mille, Matthew M.
ORCID
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Other Contributors
Xu, Xie George
Caracappa, Peter
Liu, Li (Emily)
Walczyk, Daniel F.
Yazici, Birsen
Zimmerman, Brian E.
Issue Date
2013-12
Keywords
Nuclear engineering and science
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
An experimental investigation of the tumor shape effect necessarily requires tumor phantoms of multiple shapes. Hence, a prerequisite for this research was the design and fabrication of hollow tumor phantoms which could be filled uniformly with radioactivity and imaged on a PET scanner. The phantom fabrication was achieved with the aid of stereolithography and included prolate ellipsoids of various axis ratios. The primary experimental method involved filling the tumor phantoms with solutions of 18F whose activity concentrations were known and traceable to primary radioactivity standards held by the National Institute of Standards and Technology (NIST). The tumor phantoms were then placed inside a Jaszczak cylinder (representing the human body) and imaged on a PET scanner located at NIST. This experimental approach allowed for the testing of: (1) The relative difference between tumors phantoms of different shapes, but same volume; (2) The overall accuracy of the PET measurements in terms of a ground truth reference value. Theoretical calculations of the tumor shape effect were also performed by mathematically convolving the phantom shapes with a 3D Gaussian point-spread function, and the results of the calculations were compared with the experimental data.
Description
December 2013
School of Engineering
Department
Dept. of Mechanical, Aerospace, and Nuclear Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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