Molecular determinants of the thermal expansivity of proteins and volumetric changes upon protein denaturation
Loading...
Authors
Pandharipande, Pranav
Issue Date
2016-05
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Chemical and biological engineering
Alternative Title
Abstract
In this thesis document, I have extensively discussed a variety of molecular determinants of native state expansivity, established how the thermal expansivity obtained using PPC can be used as a probe to study protein compaction, characterized the volumetric properties of the secondary structural elements such as α-helix and β- sheet using PPC, probed the molecular determinants of the change in volume upon protein unfolding (ΔVvoid and ΔVhydration) and finally, shed light on the protein volume paradox resolution and its biological implications for life at extreme environmental conditions.
Description
May 2016
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY