Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates
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Authors
Leach, Franklin E.
Wolff, Jeremy J.
Xiao, Zhongping
Ly, Mellisa
Laremore, Tatiana N.
Arungundram, Sailaja
Al-Mafraji, Kanar
Venot, Andre
Boons, Geert Jan
Linhardt, Robert J.
Issue Date
2011-01-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Electron transfer through gas-phase ion–ion reactions has led to the widespread application ofelectron-based techniques once only capable in ion trapping mass spectrometers. Although anymass analyzer can, in theory, be coupled to an ion–ion reaction device (typically a 3-D ion trap),some systems of interest exceed the capabilities of most mass spectrometers. This case isparticularly true in the structural characterization of glycosaminoglycan (GAG) oligosaccharides.To adequately characterize highly sulfated GAGs or oligosac charides above the tetrasaccharidelevel, a high-resolution mass analyzer is required. To extend previous efforts on an ion trap massspectrometer, negative electron transfer dissociation coupled with a Fourier transform ioncyclotron resonance mass spectrometer has been applied to increasingly sulfated heparan sulfateand heparin tetrasaccharides as well as a dermatan sulfate octasaccharide. Results similar to thoseobtained by electron detachment dissociation are observed.
Description
European Journal of Mass Spectrometry, 71, 167-176
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates, F. E. Leach, J. J. Wolff, Z. Xiao, M. Ly, T. N. Laremore, S. Arungundram, K. Al-Mafraji, A. Venot, G.-J. Boons, R. J. Linhardt, I. Jonathan Amster, European Journal of Mass Spectrometry, 71, 167-176, 2011.
Publisher
Sage
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
14690667