Non-anticoagulant low molecular weight heparins for pharmaceutical applications
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Authors
Ouyang, Yilan
Yu, Yanlei
Zhang, Fuming
Chen, Jianle
Han, Xiaorui
Xia, Ke
Yao, Yiming
Zhang, Zhenqing
Linhardt, Robert J.
Issue Date
2019-01-24
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Heparin is a polypharmacological agent with anticoagulant activity. Periodate oxidation of the nonsulfated glucuronic acid residue results in non-anticoagulant heparin derivative (NACH) of reduced molecular weight. Similar treatment of a low molecular weight heparin, dalteparin, also removes its anticoagulant activity, affording a second heparin derivative (D-NACH). A full structural characterization of these two derivatives reveals their structural differences. SPR studies display their ability to bind to several important heparin-binding proteins, suggesting potential new therapeutic applications.
Description
Journal of Medicinal Chemistry, 62, 1067-1073
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Non-anticoagulant low molecular weight heparins for pharmaceutical applications, Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y. Yao, Z. Zhang, R. J. Linhardt, Journal of Medicinal Chemistry, 62, 1067-1073, 2019.
Publisher
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
15204804
222623
222623