Dengue Virus Infectivity Depends on Envelope Protein Binding to Target Cell Heparan Sulfate

Authors
Chen, Yaping
Maguire, Terry
Hileman, Ronald E.
Fromm, Jonathan R.
Esko, Jeffrey D.
Linhardt, Robert J.
Marks, Rory M.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
1997-08-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Dengue Virus Infectivity Depends on Envelope Protein Binding toTarget Cell Heparan Sulfate, Y. Chen, T. Maguire, R. E. Hileman, J. R.Fromm, J. D. Esko, R.J. Linhardt, R. M. Marks, Nature Medicine,3,866-871, 1997.
Abstract
Dengue virus is a human pathogen that has reemerged as an increasingly important public health threat. We found that the cellular receptor utilized by dengue envelope protein to bind to target cells is a highly sulfated type of heparan sulfate. Heparin, highly sulfated heparan sulfate, and the polysulfonate pharmaceutical Suramin effectively prevented dengue virus infection of target cells, indicating that the envelope protein-target cell receptor interaction is a critical determinant of infectivity. The dengue envelope protein sequence includes two putative glycosaminoglycan-binding motifs at the carboxy terminus; the first could be structurally modeled and formed an unusual extended binding surface of basic amino acids. Similar motifs were also identified in the envelope proteins of other flaviviridae. Developing pharmaceuticals that inhibit target cell binding may be an effective strategy for treating flavivirus infections.
Description
Nature Medicine, 3, 866-871
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Nature Medicine
https://harc.rpi.edu/
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