Structural and mechanistic studies of Hedgehog autoprocessing
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Authors
Xie, Jian
Issue Date
2015-08
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Biochemistry and biophysics
Alternative Title
Abstract
C1 and C143 in Hint domain are essential for Hh autoprocessing. Trivalent arsenic can bind to thiol groups and can potentially be an inhibitor of Hh autoprocessing. In collaboration with Brian Callahan’s group at Binhampton University, phenylarsine oxide (PAO) has been identified as an inhibitor of Hh autoprocessing and its binding to Hint was characterized by NMR.
Description
August 2015
School of Science
School of Science
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY