Structural and mechanistic studies of Hedgehog autoprocessing

Authors
Xie, Jian
ORCID
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Other Contributors
Wang, Chunyu
Blanca, BarqueraT
Colón, Wilfredo
Linhardt, Robert J.
Issue Date
2015-08
Keywords
Biochemistry and biophysics
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
C1 and C143 in Hint domain are essential for Hh autoprocessing. Trivalent arsenic can bind to thiol groups and can potentially be an inhibitor of Hh autoprocessing. In collaboration with Brian Callahan’s group at Binhampton University, phenylarsine oxide (PAO) has been identified as an inhibitor of Hh autoprocessing and its binding to Hint was characterized by NMR.
Description
August 2015
School of Science
Department
Biochemistry and Biophysics Program
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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