Inhibition of Neuraminidase with Neuraminic Acid C-Glycosides
No Thumbnail Available
Authors
Wang, Qun
Wolff, Michael
Polat, Tülay
Du, Yuguo
Linhardt, Robert J.
Issue Date
2000-05-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Neuraminic (sialic) acid based alpha-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (Ki 15-30 microM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors.
Description
Bioorganic & Medicinal Chemistry Letters, 10, 941-944
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Inhibition of Neuraminidase with Neuraminic Acid C-Glycosides, Q. Wang, M. Wolff, T. Polat, R.J. Linhardt, Bioorganic & Medicinal Chemistry Letters, 10, 941-944, 2000.
Publisher
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
0960894X