Inhibition of Neuraminidase with Neuraminic Acid C-Glycosides

Wang, Qun
Wolff, Michael
Polat, Tülay
Du, Yuguo
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Inhibition of Neuraminidase with Neuraminic Acid C-Glycosides, Q. Wang, M. Wolff, T. Polat, R.J. Linhardt, Bioorganic & Medicinal Chemistry Letters, 10, 941-944, 2000.
Neuraminic (sialic) acid based alpha-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (Ki 15-30 microM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors.
Bioorganic & Medicinal Chemistry Letters, 10, 941-944
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The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
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Rensselaer Polytechnic Institute, Troy, NY
Bioorganic and Medicinal Chemistry Letters