Importance of Distinct Water Environments in the Hydrolysis of Poly(D,L-lactide-co-glycolide

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Authors
Schmitt, E.A.
Flanagan, D.R.
Linhardt, Robert J.
Issue Date
1994
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Article
Language
ENG
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Abstract
A detailed examination of the role of water in the hydrolysis of poly (DL-lactide/glycolide) esters is reported. The hydrolysisrate of polyester pellets was independent of moderate changes in ionic strength, pH, and buffer concentration. Total water up take by the polymer depended on ionic strength but no tpH.The hydrolysis rates were independent of thetotalwatercontentofthepolymer.Solid-state2H-NMRqualitativelydemonstratedthepresenceoftwotypesofwater(2 20)environmentswithinthepolymer,bulkwaterwithfreerotationandboundwaterwithhinderedrotation.Differentialscanningcalorimetryalsoshowedthepresenceofnonfreezingwater,confirmingdifferentwaterenvironmentswithinthepolymers.Quantitativesolid-state2H-NMRshowedthatthepolymercontainedaconstantamountofwater(2H20)withhinderedrotation.Themolarquantityofestergroupsinthepolymeris25-foldhigherthanthemolarquantityofwaterwithhinderedrotation,suggestingthatwater’simmobilityandreactivityresultfromitsselectivehydrogenbondingtotheoxygenofestercarbonylgroups.Theincreasedhydrolysisrate,observedforpolyesterswithhigherglycolidecontent,correlateswithanobservedincreaseinbound,reactivewater.
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Macromolecules, 27, 743-748,
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Full Citation
Importance of Distinct Water Environments in the Hydrolysis of Poly(D,L-lactide-co-glycolide), E.A. Schmitt, D.R. Flanagan, R.J. Linhardt, Macromolecules, 27, 743-748, 1994.
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