IO4-- stimulated crosslinking of catechol-conjugated hydroxyethylchitosan as a tissue adhesive

Authors
Peng, X.
Peng, Y.
Han, B.
Liu, W.
Zhang, F.
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2019
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
IO4-- stimulated crosslinking of catechol-conjugated hydroxyethylchitosan as a tissue adhesive, X. Peng, Y. Peng, B. Han, W. Liu, F. Zhang, R. J Linhardt, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 107B, 582-593, 2019.
Abstract
Catechol-functionalized polymers are of particular interest because of their strong water-resistant adhesive properties. Hydroxymethyl chitosan (HECTS) has been used as an implantable biomaterial having good water solubility, biodegradability and biocompatibility. Here, hydrocaffeic acid (HCA) grafted HECTS (HCA-g-HECTS) was prepared through carbodiimide coupling and the tethered catechol underwent periodate (urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0003)-stimulated mono and double cross-linking with genipin. The gelation time of these cross-linked HCA-g-HECTS hydrogels decreased with increasing molar ratio of cross-linker to grafted catechol group, increasing temperature, or the addition of genipin. Under the same molar ratio of cross-linker to catechol, urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0004-induced cross-linked HCA-g-HECTS hydrogels exhibited much stronger storage modulus and temperature stability than hydrogels made by Fe3+-triggered cross-linking. The urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0005-stimulated HCA-g-HECTS hydrogels were biocompatible on a cellular level when the molar ratio of urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0006 to catechol group was less than 0.5:1. The hydrogels prepared with a 0.125:1 molar ratio of urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0007 to catechol group exhibited high adhesion strength of 73.56 kPa against wet rat skin, and a higher adhesion strength than sutures in a rat wound closure model. This biocompatible urn:x-wiley:15524973:media:jbmb34150:jbmb34150-math-0008-stimulated HCA-g-HECTS hydrogel may represent a promising new tissue adhesive.
Description
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 107B, 582-593
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
https://harc.rpi.edu/
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