Evidence of Random Structural Features in the Heparin Polymer

Authors
Merchant, Zohar M.
Rice, Kevin G.
Kim, Yeong S.
Grant, Arthur C.
Fitzgerald, Gerald L.
Langer, Robert
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
1985-12-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
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Full Citation
Evidence of Random Structural Features in the Heparin Polymer, R.J. Linhardt, Z.M. Merchant, K.G. Rice, Y.S. Kim, G.L. Fitzgerald, A.C. Grant, R. Langer, Biochemistry, 24, 7805-7810 (1985).
Abstract
The first use of computer-simulation studies to examine heparin's structure has been reported. The product distributions obtained when porcine mucosal heparins were depolymerized with heparinase have been compared to computer-simulated distributions. The modeled distribution was relatively unaffected by the polydispersity and molecular weight of heparin. However, the percent of heparinase-cleavable glycosidic linkages and their distribution throughout the polymer resulted in a marked change in the simulated product distribution. The similarity between experimentally observed and computer-simulated product distributions is consistent with the random distribution of heparinase-cleavable sites in porcine mucosal heparin. Finally, a random distribution of N-acetyl residues with respect to heparinase-cleavable sites was experimentally observed.
Description
Biochemistry, 24, 7805-7810
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Biochemistry
https://harc.rpi.edu/
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