Evidence of Random Structural Features in the Heparin Polymer

Merchant, Zohar M.
Rice, Kevin G.
Kim, Yeong S.
Grant, Arthur C.
Fitzgerald, Gerald L.
Langer, Robert
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Evidence of Random Structural Features in the Heparin Polymer, R.J. Linhardt, Z.M. Merchant, K.G. Rice, Y.S. Kim, G.L. Fitzgerald, A.C. Grant, R. Langer, Biochemistry, 24, 7805-7810 (1985).
The first use of computer-simulation studies to examine heparin's structure has been reported. The product distributions obtained when porcine mucosal heparins were depolymerized with heparinase have been compared to computer-simulated distributions. The modeled distribution was relatively unaffected by the polydispersity and molecular weight of heparin. However, the percent of heparinase-cleavable glycosidic linkages and their distribution throughout the polymer resulted in a marked change in the simulated product distribution. The similarity between experimentally observed and computer-simulated product distributions is consistent with the random distribution of heparinase-cleavable sites in porcine mucosal heparin. Finally, a random distribution of N-acetyl residues with respect to heparinase-cleavable sites was experimentally observed.
Biochemistry, 24, 7805-7810
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