E. coli K5 heparosan fermentation and improvement by genetic engineering

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Authors
Wang, Z.
Dordick, J.S.
Linhardt, Robert J.
Issue Date
2011
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Abstract
N-acetyl heparosan is the precursor for the biosynthesis of the important anticoagulant drug heparin. The E. coli K5 capsular heparosan polysaccharide provides a promising precursor for in vitro chemoenzymatic production of bioengineered heparin. This article explores the improvements of heparosan production for bioengineered heparin by fermentation process engineering and genetic engineering.
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Bioengineered Bugs, 2, 1-15
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E. coli K5 heparosan fermentation and improvement by genetic engineering, Z. Wang, J. S. Dordick, R. J. Linhardt, Bioengineered Bugs, 2, 1-15, 2011.
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