E. coli K5 heparosan fermentation and improvement by genetic engineering
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https://orcid.org/0000-0003-2219-5833
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Article
Language
ENG
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Abstract
N-acetyl heparosan is the precursor for the biosynthesis of the important anticoagulant drug heparin. The E. coli K5 capsular heparosan polysaccharide provides a promising precursor for in vitro chemoenzymatic production of bioengineered heparin. This article explores the improvements of heparosan production for bioengineered heparin by fermentation process engineering and genetic engineering.
Description
Bioengineered Bugs, 2, 1-15
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
E. coli K5 heparosan fermentation and improvement by genetic engineering, Z. Wang, J. S. Dordick, R. J. Linhardt, Bioengineered Bugs, 2, 1-15, 2011.