Elucidating the mechanism of magnetogenetics
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Authors
Brier, Matthew I.
Issue Date
2020-05
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Chemical engineering
Alternative Title
Abstract
Understanding how cells regulate physiological functions has become an area of significant interest in both the fields of bioengineering and medicine. Great strides have been made in understanding cell signaling pathways, how they regulate cell functions, and their relationship to abnormal or diseased states. Progress in these areas has led to a number of genetic platforms that can be introduced to an organism and remotely stimulated to regulate cellular processes and control cell physiology. Magnetogenetics is one such platform that has been demonstrated to remotely control intracellular signaling and gene expression in vitro and metabolism and behavior in vivo with high spatiotemporal resolution; however there remains a void in the fundamental understanding of magnetogenetic platforms. This dissertation research focused on filling this void and elucidating the mechanism of control underlying a magnetogenetic platform composed of genetically encoded magnetic nanoparticles (ferritin) conjugated to a cellular membrane calcium ion channel (transient receptor potential vanilloid 1, TRPV1).
Description
May 2020
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY