Chemically modified polysaccharides: Synthesis, characterization, structure activity relationships of action

Authors
Xu, Yong
Wu, Yu ji
Sun, Pei long
Zhang, Fu ming
Linhardt, Robert J.
Zhang, An qiang
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2019-07-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Chemically modified polysaccharides: Synthesis, characterization, structure activity relationships of action, Y. Xu, Y.-J. Wu, P.-L. Sun, F. Zhang, R. J. Linhardt, A. Zhang, International Journal of Biological Macromolecules, 132, 970–977, 2019.
Abstract
Polysaccharides are a major class of biomacromolecules. Their bioactivities depend on chemical structure, which includes monosaccharide composition, linkages below sugar residues, and solution conformation. Many researchers report that chemical modifications of polysaccharides lead to a significantly increase in the structural diversity, promoting bioactivity and even add new bioactivities, including antioxidant and anti-tumor properties as well as anticoagulant and immunoregulatory activities. This paper reviews the recent progress of chemical modification of polysaccharides, including i) the common synthetic methods of chemical modification; ii) their structural characterization; iii) their bioactivities; and iv) the structure activity relationships of these modified polysaccharides. This review also suggests future directions for researchers and new applications for chemically modified polysaccharide derivatives in the pharmaceutical and food industries.
Description
International Journal of Biological Macromolecules, 132, 970–977
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
International Journal of Biological Macromolecules
https://harc.rpi.edu/
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