Chemically modified polysaccharides: Synthesis, characterization, structure activity relationships of action

Xu, Yong
Wu, Yu ji
Sun, Pei long
Zhang, Fu ming
Linhardt, Robert J.
Zhang, An qiang
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Chemically modified polysaccharides: Synthesis, characterization, structure activity relationships of action, Y. Xu, Y.-J. Wu, P.-L. Sun, F. Zhang, R. J. Linhardt, A. Zhang, International Journal of Biological Macromolecules, 132, 970–977, 2019.
Polysaccharides are a major class of biomacromolecules. Their bioactivities depend on chemical structure, which includes monosaccharide composition, linkages below sugar residues, and solution conformation. Many researchers report that chemical modifications of polysaccharides lead to a significantly increase in the structural diversity, promoting bioactivity and even add new bioactivities, including antioxidant and anti-tumor properties as well as anticoagulant and immunoregulatory activities. This paper reviews the recent progress of chemical modification of polysaccharides, including i) the common synthetic methods of chemical modification; ii) their structural characterization; iii) their bioactivities; and iv) the structure activity relationships of these modified polysaccharides. This review also suggests future directions for researchers and new applications for chemically modified polysaccharide derivatives in the pharmaceutical and food industries.
International Journal of Biological Macromolecules, 132, 970–977
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
International Journal of Biological Macromolecules