Visualizing pathways: An exploration of the protein unfolding process

Authors
Matthews, Suzanne J.
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Other Contributors
Bystroff, Christopher, 1960-
Issue Date
2008-05
Keywords
Computer science
Degree
MS
Terms of Use
Attribution-NonCommercial-NoDerivs 3.0 United States
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
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Abstract
Proteins are the essential macromolecular workhorses that govern most life processes. Understanding how proteins fold will better assist in protein structure prediction, protein design, and understanding the pathology of certain diseases. The notion and existence of protein folding and unfolding pathways is supported by a volume of research. It has further been suggested that the paths of folding and unfolding are the one in the same. With this in mind, the GeoFold suite was created in order to help researchers visualize the pathway of folding/unfolding. Since a protein's state space is more restricted from an unfolding approach, simulation time and memory costs can be cut down, allowing for the visualizing of large proteins. The result is a useful tool that allows for the visualization of the predicted dominant folding pathway of a protein of virtually any size.
Description
May 2008
School of Science
Department
Dept. of Computer Science
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
Access
CC BY-NC-ND. Users may download and share copies with attribution in accordance with a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License. No commercial use or derivatives are permitted without the explicit approval of the author.