Recent Progress and Advanced Technology in Carbohydrate-Based Drug Development
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Authors
Pan, Lin
Cai, Chao
Liu, Chanjuan
Liu, Di
Li, Guoyun
Linhardt, Robert J.
Yu, Guangli
Issue Date
2021-06-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Carbohydrates, one of the most abundant and widespread biomolecules in nature, play indispensable roles in diverse biological functions, and represent a treasure trove of untapped potential for pharmaceutical applications. Here, we provide a brief overview of carbohydrate-based drug development (CBDD) over the past two decades. More importantly, advanced techniques and methodologies related to CBDD are emerging, including enzymatic synthesis, metabolic engineering, site-specific glycoconjugation, carbohydrate libraries and microarrays as well as carbohydrate-gut microbiome evaluation. These technologies have dramatically accelerated the speed of CBDD. The recently approved drugs and emerging techniques summarized herein will inspire new sights into potential opportunities to discover novel carbohydrate drugs.
Description
Current Opinions in Biotechnology, 69, 191–198
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Recent Progress and Advanced Technology in Carbohydrate-Based Drug Development, L. Pan, C. Cai, C. Liu, D. Liu, G. Li, R. J. Linhardt, G. Yu, Current Opinions in Biotechnology, 69, 191–198, 2021.
Publisher
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
18790429
9581669
9581669