Construction and Characterization of Heparan Sulfate Heptasaccharide Microarray
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Authors
Yang, Jianhong
Hsieh, Po Hung
Liu, Xinyue
Zhou, Wen
Zhang, Xing
Zhao, Jing
Xu, Yongmei
Zhang, Fuming
Linhardt, Robert J.
Liu, Jian
Issue Date
2017-01-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.
Description
Chemical Communications, 53, 1743-1746
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Construction and Characterization of Heparan Sulfate Heptasaccharide Microarray, J. Yang, P.-H.Hsieh, X. Liu, W. Zhou, X. Zhang, F. Zhang, R. J. Linhardt, J. Liu, Chemical Communications, 53, 1743-1746, 2017.
Publisher
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
1364548X
13597345
13597345