Construction and Characterization of Heparan Sulfate Heptasaccharide Microarray

Yang, Jianhong
Hsieh, Po Hung
Liu, Xinyue
Zhou, Wen
Zhang, Xing
Zhao, Jing
Xu, Yongmei
Zhang, Fuming
Linhardt, Robert J.
Liu, Jian
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Construction and Characterization of Heparan Sulfate Heptasaccharide Microarray, J. Yang, P.-H.Hsieh, X. Liu, W. Zhou, X. Zhang, F. Zhang, R. J. Linhardt, J. Liu, Chemical Communications, 53, 1743-1746, 2017.
A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.
Chemical Communications, 53, 1743-1746
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
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Rensselaer Polytechnic Institute, Troy, NY
Chemical Communications