Investigating Na+ binding sites in the Na+-translocating NADH:ubiquinone dehydrogenase (Na+-NQR)

Authors
Mezic, Katherine Gloria
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Other Contributors
Barquera, Blanca L.
Hellwig, Petra
Makhatadze, George I.
Royer, Catherine Ann
Issue Date
2018-05
Keywords
Biochemistry and biophysics
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
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Abstract
This work has allowed us to propose a completely new mechanism of Na+ translocation. If the Na+ uptake and translocation pathways are characterized, they can then be linked to the conformational changes in the enzyme that are related to the redox state of various cofactors. Ultimately, this information can be used to define the coupling mechanism in Na+-NQR. By understanding how Na+-NQR carries out its function, we will gain insight into bacterial adaptation in different environments.
Description
May 2018
School of Science
Department
Biochemistry and Biophysics Program
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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