Synthesis of Double C-Glycoside Analog of sTn
Loading...
Authors
Ress, Dino K.
Baytas, Sultan N.
Wang, Qun
Muñoz, Eva M.
Tokuzoki, Kazuo
Tomiyama, Hiroshi
Linhardt, Robert J.
Issue Date
2005-09-20
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
A sTn double C-glycoside, sTn analogue 2, was synthesized using samarium chemistry developed in our laboratory. Complications in the oxidation reaction affording aldehyde acceptor were overcome by double protection of amide and the use of a room-temperature ionic liquid as solvent. Studies are underway to conjugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vaccine.
Description
Journal of Organic Chemistry, 70, 8197-8200
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Synthesis of Double C-Glycoside Analog of sTn, D.R. Ress, S.N. Baytas, H Tomiyama, E.M. Muñoz, R.J. Linhardt, Journal of Organic Chemistry, 70, 8197-8200, 2005.
Publisher
American Chemical Society (ACS)
Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
223263