Synthesis of Double C-Glycoside Analog of sTn

Ress, Dino K.
Baytas, Sultan N.
Wang, Qun
Muñoz, Eva M.
Tokuzoki, Kazuo
Tomiyama, Hiroshi
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Synthesis of Double C-Glycoside Analog of sTn, D.R. Ress, S.N. Baytas, H Tomiyama, E.M. Muñoz, R.J. Linhardt, Journal of Organic Chemistry, 70, 8197-8200, 2005.
A sTn double C-glycoside, sTn analogue 2, was synthesized using samarium chemistry developed in our laboratory. Complications in the oxidation reaction affording aldehyde acceptor were overcome by double protection of amide and the use of a room-temperature ionic liquid as solvent. Studies are underway to conjugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vaccine.
Journal of Organic Chemistry, 70, 8197-8200
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
American Chemical Society (ACS)
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Journal of Organic Chemistry
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