Synthesis of Double C-Glycoside Analog of sTn

Authors
Ress, Dino K.
Baytas, Sultan N.
Wang, Qun
Muñoz, Eva M.
Tokuzoki, Kazuo
Tomiyama, Hiroshi
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Issue Date
2005-09-20
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Full Citation
Synthesis of Double C-Glycoside Analog of sTn, D.R. Ress, S.N. Baytas, H Tomiyama, E.M. Muñoz, R.J. Linhardt, Journal of Organic Chemistry, 70, 8197-8200, 2005.
Abstract
A sTn double C-glycoside, sTn analogue 2, was synthesized using samarium chemistry developed in our laboratory. Complications in the oxidation reaction affording aldehyde acceptor were overcome by double protection of amide and the use of a room-temperature ionic liquid as solvent. Studies are underway to conjugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vaccine.
Description
Journal of Organic Chemistry, 70, 8197-8200
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
American Chemical Society (ACS)
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Journal of Organic Chemistry
https://harc.rpi.edu/
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