Immobilization of Heparin-Approaches and Applications

Murugesan, Saravanababu
Xie, Jin
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Immobilization of Heparin-Approaches and Applications, S. Murugesan, J. Xie, R. J. Linhardt, Current Topics in Medicinal Chemistry, 8, 80-100, 2008.
Heparin, an anticoagulant, has been used in many forms to treat various diseases. These forms include soluble heparin and heparin immobilized to supporting matrices by physical adsorption, by covalent chemical methods and by photochemical attachment. These immobilization methods often require the use of spacers or linkers. This review examines and compares various techniques that have been used for the immobilization of heparin as well as applications of these immobilized heparins. In the applications reviewed, immobilized heparin is compared with soluble heparin for efficient and versatile use in each of the various applications.
Current Topics in Medicinal Chemistry, 8, 80-100
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Bentham Science
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Current Topics in Medicinal Chemistry
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