Immobilization of Heparin-Approaches and Applications

Authors
Murugesan, Saravanababu
Xie, Jin
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Issue Date
2008-01-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Full Citation
Immobilization of Heparin-Approaches and Applications, S. Murugesan, J. Xie, R. J. Linhardt, Current Topics in Medicinal Chemistry, 8, 80-100, 2008.
Abstract
Heparin, an anticoagulant, has been used in many forms to treat various diseases. These forms include soluble heparin and heparin immobilized to supporting matrices by physical adsorption, by covalent chemical methods and by photochemical attachment. These immobilization methods often require the use of spacers or linkers. This review examines and compares various techniques that have been used for the immobilization of heparin as well as applications of these immobilized heparins. In the applications reviewed, immobilized heparin is compared with soluble heparin for efficient and versatile use in each of the various applications.
Description
Current Topics in Medicinal Chemistry, 8, 80-100
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Bentham Science
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Current Topics in Medicinal Chemistry
https://harc.rpi.edu/
Access
A full text version is available in DSpace@RPI