Immobilization of Heparin-Approaches and Applications

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Authors
Murugesan, Saravanababu
Xie, Jin
Linhardt, Robert J.
Issue Date
2008-01-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Abstract
Heparin, an anticoagulant, has been used in many forms to treat various diseases. These forms include soluble heparin and heparin immobilized to supporting matrices by physical adsorption, by covalent chemical methods and by photochemical attachment. These immobilization methods often require the use of spacers or linkers. This review examines and compares various techniques that have been used for the immobilization of heparin as well as applications of these immobilized heparins. In the applications reviewed, immobilized heparin is compared with soluble heparin for efficient and versatile use in each of the various applications.
Description
Current Topics in Medicinal Chemistry, 8, 80-100
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Immobilization of Heparin-Approaches and Applications, S. Murugesan, J. Xie, R. J. Linhardt, Current Topics in Medicinal Chemistry, 8, 80-100, 2008.
Publisher
Bentham Science
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ISSN
15680266
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