Urinary metabolomics analysis reveals the anti-diabetic effect of stachyose in high-fat diet/ streptozotocin - induced type 2 diabetic rats
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Authors
Liang, Li
Liu, Guimei
Yu, Guoyong
Zhang, Fuming
Linhardt, Robert J.
Li, Quanhong
Issue Date
2020-02-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
As a new platform of systems biology, metabolomics provides a powerful approach to discover therapeutic biomarkers and mechanism of metabolic disease. Type 2 diabetes mellitus (T2DM) is a global metabolic disease, thus, a urinary metabolomics profiling was analyzed to study the anti-diabetic effects and mechanism of stachyose (ST) on high-fat diet- and low dose streptozotocinc-induced T2DM rats. The results showed that ST treatment regulated the level of insulin, low-density lipoprotein cholesterol, and triglycerides, which demonstrates improvement in T2DM on ST treatment. Urinary samples from the ST and T2DM group were enrolled in metabolomics study, 21 differential metabolites were identified from urinary metabolomics analysis, indicating that the ST treatment partly exerted the anti-diabetes activity by regulating energy metabolism, gut microbiota changes and inflammation. A metabolomics strategy is both suitable and reliable for exploring the anti-diabetes effects and understanding the mechanisms of ST treatment against T2DM.
Description
Carbohydrate Polymers, 229, 115534
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Urinary metabolomics analysis reveals the anti-diabetic effect of stachyose in high-fat diet/ streptozotocin - induced type 2 diabetic rats, L. Liang, G. Liu, F. Zhang, R. J. Linhardt, Q. Li, Carbohydrate Polymers, 229, 115534, 2020.
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PubMed ID
DOI
ISSN
1448617