Understanding the mechanisms behind cardiac and skeletal muscle disease
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Authors
Bell, Kaylyn M.
Issue Date
2019-08
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Biochemistry and biophysics
Alternative Title
Abstract
Muscle and how it functions has been studied for decades, yet the molecular mechanisms behind muscle disease are still not fully understood. This dissertation provides a collection of studies that investigate molecular mechanisms behind the muscle diseases hypertrophic cardiomyopathy (HCM), Freeman-Sheldon syndrome (FSS), as well as the muscle phenomenon stretch activation (SA). I used the model organism Drosophila melanogaster, and the main focus is the role of myosin heavy chain (MHC) in these mechanisms.
Description
August 2019
School of Science
School of Science
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY