Understanding the mechanisms behind cardiac and skeletal muscle disease

Authors
Bell, Kaylyn M.
ORCID
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Other Contributors
Swank, Douglas M.
Gilbert, Susan P.
Barquera, Blanca L.
Corr, David T.
Issue Date
2019-08
Keywords
Biochemistry and biophysics
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
Muscle and how it functions has been studied for decades, yet the molecular mechanisms behind muscle disease are still not fully understood. This dissertation provides a collection of studies that investigate molecular mechanisms behind the muscle diseases hypertrophic cardiomyopathy (HCM), Freeman-Sheldon syndrome (FSS), as well as the muscle phenomenon stretch activation (SA). I used the model organism Drosophila melanogaster, and the main focus is the role of myosin heavy chain (MHC) in these mechanisms.
Description
August 2019
School of Science
Department
Biochemistry and Biophysics Program
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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