Draft Genome Sequence of Escherichia coli Strain Nissle 1917 1 (Serovar O6:K5:H1)

Cress, B.F.
Linhardt, Robert J.
Koffas, M.A.G.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Draft Genome Sequence of Escherichia coli Strain Nissle 1917 1 (Serovar O6:K5:H1), B. F. Cress, R. J. Linhardt, M.A.G. Koffas, Genome Announcements, 1, e00047-13, 2013.
We announce the availability of the 5.023-Mbp high-quality draft assembly of the Escherichia coli strain Nissle 1917 (serovar O6:K5:H1) genome. Short genomic segments from this important probiotic strain have been available in public databases, but the full genome sequence has remained inaccessible. Thus, high-coverage, whole genome sequencing of E. coli Nissle 1917 is presented herein. Reannotation and metabolic reconstruction will enable comparative genomics analysis and model-guided predictions of genetic manipulations leading to increased production of the K5 capsular polysaccharide known as N-acetyl heparosan, a precursor to the anticoagulant pharmaceutical heparin.
Genome Announcements, 1, e00047-13
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The American Society for Microbiology (ASM)
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
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