Structure and bioactivity of a polysaccharide containing uronic acid from Polyporus umbellatus sclerotia

He, Pengfei
Zhang, Anqiang
Zhang, Fuming
Linhardt, Robert J.
Sun, Peilong
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Structure and bioactivity of a polysaccharide containing uronic acid from Polyporus umbellatus sclerotia, P. He, A. Zhang, F. Zhang, R. J. Linhardt, P. Sun, Carbohydrate Polymers,152, 222–230, 2016.
Polyporus umbellatus is a medicinal fungus, has been used in traditional Chinese medicine for thousands years for treatment of edema, scanty urine, vaginal discharge, jaundice and diarrhea. The structure of a soluble polysaccharide (named PUP80S1), purified from the sclerotia of Polyporus umbellatus was elucidated by gas chromatography (GC), GC–mass spectrometry and nuclear magnetic resonance spectroscopy. PUP80S1 is a branched polysaccharide containing approximately 8.5% uronic acid and having an average molecular weight of 8.8 kDa. Atomic force microscopy of PUP80S1 reveals a globular chain conformation in water. Antioxidant tests, Oxygen radical absorption capacity and 2,2-diphenyl-1-picrylhydrazyl radical scavenging assays indicate that PUP80S1 possesses significant antioxidant activity. But the related polysaccharide, PUP60S2, which contains more uronic acid residues and a higher level of branching, shows better antioxidant activity. These results suggest that structure features of polysaccharides play an important role in their physiological functions.
Carbohydrate Polymers,152, 222–230
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Carbohydrate Polymers