Structural characterization of a clinically described heparin-like substance in plasma causing bleeding

Yu, Yanlei
Bruzdoski, Karen
Kostousov, Vadim
Hensch, Lisa
Hui, Shiu ki
Siddiqui, Fakiha
Farooqui, Amber
Kouta, Ahmed
Zhang, Fuming
Fareed, Jawed
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Structural characterization of a clinically described heparin-like substance in plasma causing bleeding, Y. Yu, K. Bruzdoski, V. Kostousov, L. Hensch, S. Hui, F. Siddiqui, A. Farooqui, A. Kouta, F. Zhang, J. Fareed, J. Teruya, R. J. Linhardt, Carbohydrate Polymers, 244, 116443, 2020.
Heparin-like substances (HLS) have been described in various clinical situations, including in settings of liver disease associated with infection, transplant, and metastasis. HLS are generally attributed to circulating glycosaminoglycans. Initial results for this patient showed coagulopathy due to liver disease without HLS. Two weeks after liver transplantation, a 10 year-old female with liver failure patient began to bleed from catheter insertion sites, mouth, and nares and HLS was suspected. The patient subsequently died and these clinical samples resulted in the isolation of a single heparan sulfate (HS) present at high concentrations in the plasma. Analysis of this HS showed it had an intermediate between heparin and HS with low antithrombin-mediated anticoagulant activity. We speculate that this 10-year old patient might have a platelet function defect influenced by this unusual HS. Endothelial defects not measurable by our methods might have also contributed to the observed bleeding complications.
Carbohydrate Polymers, 244, 116443
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Carbohydrate Polymers
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