Carbon Inhibits VEGF and FGF Promoted Angiogenesis

Murugesan, S.
Mousa, S.A.
O’Connor, L.J.
Lincoln, D.W.
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Carbon Inhibits VEGF and FGF Promoted Angiogenesis, S. Murugesan, S. A. Mousa, L. J. O’Connor, D.W. Lincoln, R. J. Linhardt, FEBS Letters, 581, 1157-1160, 2007.
Angiogenesis is important for normal growth and wound healing processes. An imbalance of the growth factors involved in this process, however, causes the acceleration of several diseases including malignant, ocular, and inflammatory diseases. Inhibiting angiogenesis through interfering in its pathway is a promising methodology to hinder the progression of these diseases. Herein, we studied the anti-angiogenic effects of various carbon materials such as graphite, multiwalled carbon nanotubes and fullerenes in vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF2)-induced angiogenesis evaluated in the chick chorioallantoic membrane (CAM) model. All the carbon materials tested showed substantial anti-angiogenic activity against either FGF2- or VEGF-induced angiogenesis in the CAM model. Those carbon materials did not have any significant effects on basal angiogenesis in the absence of the added growth factors.
FEBS Letters, 581, 1157-1160
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
FEBS Press
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
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