A Highly Stable Covalent Conjugated Heparin Biochip for Heparin-Protein Interactions Studies
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Authors
Zhang, Fuming
Fath, Melissa
Marks, Rory
Linhardt, Robert J.
Issue Date
2002-05-15
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Heparin is a proteoglycan composed of highly sulfated linear polysaccharides of alternating uronic acid and glucosamine that interacts with a wide variety of proteins and peptides (1). Heparin and the structurally related heparan sulfate are the most acidic polysaccarides in the human body and, as a result, interact with many cationic proteins, giving rise to myriad biological activities (2). Some of these interactions have received extensive attention in recent years, including heparin’s binding to growth factors (3, 4) influencing angiogenesis and other proliferation-dependent processes, and its binding to the ectodomain proteins of pathogens influencing infection.
Description
Analytical Biochemistry, 304, 271-273
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
A Highly Stable Covalent Conjugated Heparin Biochip for Heparin-Protein Interactions Studies, F. Zhang, M. Fath, R. Marks, R.J. Linhardt, Analytical Biochemistry, 304, 271-273, 2002.
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PubMed ID
DOI
ISSN
32697