An Enzymatic System for Removing Heparin in Extracorporeal Therapy
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Authors
Langer, Robert
Linhardt, Robert J.
Hoffberg, Steven
Larsen, Annette K.
Cooney, Charles L.
Tapper, David
Klein, Michael
Issue Date
1982-01-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.
Description
Science, 217, 261-263
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
An Enzymatic System for Removing Heparin in Extracorporeal Therapy, R. Langer, R.J. Linhardt, C.L. Cooney, M. Klein, D. Tapper, S.M. Hoffberg, A. Larsen, Science, 217, 261-263 (1982).
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Terms of Use
Journal
Volume
Issue
PubMed ID
DOI
ISSN
368075