An Enzymatic System for Removing Heparin in Extracorporeal Therapy

Langer, Robert
Linhardt, Robert J.
Hoffberg, Steven
Larsen, Annette K.
Cooney, Charles L.
Tapper, David
Klein, Michael
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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An Enzymatic System for Removing Heparin in Extracorporeal Therapy, R. Langer, R.J. Linhardt, C.L. Cooney, M. Klein, D. Tapper, S.M. Hoffberg, A. Larsen, Science, 217, 261-263 (1982).
The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.
Science, 217, 261-263
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
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Rensselaer Polytechnic Institute, Troy, NY