Time-resolved hyperspectral compressive single-pixel wide-field optical imaging
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Authors
Pian, Qi
Issue Date
2017-08
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Biomedical engineering
Alternative Title
Abstract
The characteristics of Hadamard matrix-based 2D spatial multiplexing on the proposed platform, regarding information content and noise, were analyzed theoretically and validated experimentally. Further, the system performance for hyperspectral 2D spatial multiplexing was validated in lifetime-enhanced molecular imaging. Quantitative investigations of in vitro antibody reactions and in vivo ligand-receptor engagement were demonstrated via sensing of FRET (Förster resonance energy transfer) signals. The quantitative accuracy of the proposed system was benchmarked against a well-established gated intensified CCD-based system and found to be within ±6% absolute margin of the ground truth.
Description
August 2017
School of Engineering
School of Engineering
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY