The effects of biophysical stimuli on select bone cell functions pertinent to osteogenesis

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Authors
Supronowicz, Peter R.
Issue Date
2002-05
Type
Electronic thesis
Thesis
Language
ENG
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Biomedical engineering
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Abstract
Although electric, pulsed electromagnetic, and magnetic fields have been used in attempts to accelerate bone repair in animal models and in clinical studies, the underlying cellular/molecular mechanisms responsible for new bone formation under these conditions are still not fully understood. Motivated by this need, the present in vitro study designed, assembled, and used novel laboratory systems to examine, and finally compare, the effects of alternating current, pulsed electromagnetic fields, and magnetic fields on select functions of osteoblasts (the bone-forming cells) pertinent to bone formation. The cell functions investigated were cell adhesion, proliferation, and gene expression of select bone-matrix proteins. In addition, calcium mineral accumulation, and index of formation of the inorganic phase of bone, in the extra cellular matrix of osteoblasts was also quantified.
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May 2002
School of Engineering
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Rensselaer Polytechnic Institute, Troy, NY
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