Preparation and anticoagulant activity of phosphosulfomannan PI-88

Authors
Yu, Guangli
Gunay, Nur Sibel
Linhardt, Robert J.
Toida, Toshihiko
Fareed, Jawed
Hoppensteadt, Debra A.
Shadid, Hazar
Ferro, Vito
Li, Caiping
Fewings, Kym
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2002-10-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Preparation and anticoagulant activity of phosphosulfomannan PI-88, G. Yu, N.S Gunay, R.J Linhardt, T. Toida, J. Fareed, D.A. Hoppensteadt, H. Shadid, V. Ferro, C. Li, K. Fewings, M.C. Palermo, D. Podger, European Journal of Medicinal Chemistry, 37, 783-791, 2002.
Abstract
A yeast-derived phosphomannan mixture was chemically sulfonated and the composition and structure of the product mixture was studied. This phosphosulfomannan mixture, PI-88, is currently under clinical evaluation as an anti-cancer agent. Analysis using capillary electrophoresis demonstrated that PI-88 was a multi-component mixture. Gel permeation chromatography provided four fractions of PI-88 that contained components which differed in size from disaccharide to hexasaccharide, and by degree of sulfation. These fractions were characterised by spectroscopic and chromatographic methods and the structure of PI-88 is that expected based on the structure of the phosphomannan starting material. The anticoagulant activity of these fractions was evaluated and the structural requirements for activity are described.
Description
European Journal of Medicinal Chemistry, 37, 783-791
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
European Journal of Medicinal Chemistry
https://harc.rpi.edu/
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