Preparation and anticoagulant activity of phosphosulfomannan PI-88
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Authors
Yu, Guangli
Gunay, Nur Sibel
Linhardt, Robert J.
Toida, Toshihiko
Fareed, Jawed
Hoppensteadt, Debra A.
Shadid, Hazar
Ferro, Vito
Li, Caiping
Fewings, Kym
Issue Date
2002-10-01
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
A yeast-derived phosphomannan mixture was chemically sulfonated and the composition and structure of the product mixture was studied. This phosphosulfomannan mixture, PI-88, is currently under clinical evaluation as an anti-cancer agent. Analysis using capillary electrophoresis demonstrated that PI-88 was a multi-component mixture. Gel permeation chromatography provided four fractions of PI-88 that contained components which differed in size from disaccharide to hexasaccharide, and by degree of sulfation. These fractions were characterised by spectroscopic and chromatographic methods and the structure of PI-88 is that expected based on the structure of the phosphomannan starting material. The anticoagulant activity of these fractions was evaluated and the structural requirements for activity are described.
Description
European Journal of Medicinal Chemistry, 37, 783-791
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Preparation and anticoagulant activity of phosphosulfomannan PI-88, G. Yu, N.S Gunay, R.J Linhardt, T. Toida, J. Fareed, D.A. Hoppensteadt, H. Shadid, V. Ferro, C. Li, K. Fewings, M.C. Palermo, D. Podger, European Journal of Medicinal Chemistry, 37, 783-791, 2002.
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PubMed ID
DOI
ISSN
2235234