Mass Spectrometry for the Analysis of Highly Charged Sulfated Carbohydrates

Chi, L.
Amster, J.
Linhardt, Robert J.
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Mass Spectrometry for the Analysis of Highly Charged Sulfated Carbohydrates, L. Chi, J. Amster, R.J. Linhardt, Current Analytical Chemistry,1, 223-240, 2005.
Sulfated polysaccharides and their oligosaccharide components play an important biological role in physiological and pathophysiological processes. Glycosaminoglycans, such as heparin, are currently used as pharmaceutical agents to control coagulation. Moreover, there arc intensive efforts in developing rapid approaches for the analysis of such bioactive carbohydrates to assess their pharmacological activity and in glycomic applications. Soft ionization methods of mass spectrometry have been applied with recent success in the analysis of sulfated carbohydrates. This review will examine the application of mass spectrometry in the compositional analysis and structural characterization of these important highly charged molecules.
Current Analytical Chemistry,1, 223-240
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Bentham Science
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
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