Mass Spectrometry for the Analysis of Highly Charged Sulfated Carbohydrates
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Authors
Chi, L.
Amster, J.
Linhardt, Robert J.
Issue Date
2005
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Sulfated polysaccharides and their oligosaccharide components play an important biological role in physiological and pathophysiological processes. Glycosaminoglycans, such as heparin, are currently used as pharmaceutical agents to control coagulation. Moreover, there arc intensive efforts in developing rapid approaches for the analysis of such bioactive carbohydrates to assess their pharmacological activity and in glycomic applications. Soft ionization methods of mass spectrometry have been applied with recent success in the analysis of sulfated carbohydrates. This review will examine the application of mass spectrometry in the compositional analysis and structural characterization of these important highly charged molecules.
Description
Current Analytical Chemistry,1, 223-240
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Mass Spectrometry for the Analysis of Highly Charged Sulfated Carbohydrates, L. Chi, J. Amster, R.J. Linhardt, Current Analytical Chemistry,1, 223-240, 2005.
Publisher
Bentham Science