Characterization of the thymidine kinase in herpes virus-transformed cells
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Authors
Staczek, John
Issue Date
1976-12
Type
Electronic thesis
Thesis
Thesis
Language
ENG
Keywords
Biology
Alternative Title
Abstract
Herpes simplex virus Type 2 (HSV-2) also codes for a thymidine kinase which is different from the cytosol or mitochondrial forms of the enzyme. Cells lytically infected with HSV-2 have a viral enzyme with a PAGE mobility intermediate between the cytosol and mitochondrial thymidine kinases. The viral enzyme used CTP as a phosphate donor and was very heat sensitive. Two HSV-2 transformed cell lines showed no evidence of any viral thymidine kinase when tested for their CTP specificity or thermostability. PAGE profiles showed no detectable viral enzyme activity.
Description
December 1976
School of Science
School of Science
Full Citation
Publisher
Rensselaer Polytechnic Institute, Troy, NY