Comparison of the Activity of Two Chondroitin AC Lyases on Dermatan Sulfate
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Authors
Gu, Kenan
Liu, Jian
Pervin, Azra
Linhardt, Robert J.
Issue Date
1993-06-21
Type
Article
Language
ENG
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Alternative Title
Abstract
Chondroitin sulfates are widely distributed in human and animal tissues and are the main constituents of cartilage’. The two major isomeric chondroitin sulfates, A (ChS-A) and C (ChS-C) are isolated as glycosaminoglycan from the proteoglycans present in tissues’. Structural investigations have shown that ChS-A and ChS-C both are co-polymers of D-glucuronic acid and sulfated 2-acetamido-2-deoxy-pgalactose. ChS-A primarily contains 4-sulfated 2-acetamido-2-deoxy-D-galactose residues, while ChS-C primarily contains 6-sulfated 2-acetamido-2-deoxy-o-galactose residues. Dermatan sulfate (DS) is a related glycosaminoglycan, often called chondroitin sulfate B (ChS-B), composed of 4-sulfated 2-acetamido-2-deoxy-ogalactose residues. DS differs from ChS-A and ChS-C since its primary uranic acid residue is L-iduronic acid instead of p-glucuronic acid. Despite these structural differences ChS-A, ChS-C, and DS also contain the minor uranic acid C-S epimer (L-iduronic acid in ChS-A and ChS-C and p-glucuronic acid in DS) in their structures.
Description
Carbohydrate Research, 244, 369-377
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Full Citation
Comparison of the Activity of Two Chondroitin AC Lyases on Dermatan Sulfate, K. Gu, J. Liu, A. Pervin, R.J. Linhardt, Carbohydrate Research, 244, 369-377 (1993).
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DOI
ISSN
86215