Role of Glycosaminoglycans in Cellular Communication

Linhardt, Robert J.
Toida, Toshihiko
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Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
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Role of Glycosaminoglycans in Cellular Communication, R. J. Linhardt, T. Toida, Accounts of Chemical Research, 37, 431-438, 2004.
Glycosaminoglycans are of critical importance in intercellular communication in organisms. This ubiquitous class of linear polyanions interacts with a wide variety of proteins, including growth factors and chemokines, which regulate important physiological processes. The presence of glycosaminoglycans on cell membranes and in the extracellular matrix also has resulted in their exploitation by infectious pathogens to gain access and entry into animal cells. This Account examines the structural and physical characteristics of these molecules responsible for their interaction with proteins important in cell−cell communication.
Accounts of Chemical Research, 37, 431-438
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The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Accounts of Chemical Research